Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Search Results Fulltext search 895 Results Found Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding Authors (3) Amy EM Beedle Steven LynhamSergi Garcia-Manyes Nature Communications Published 22 August 2016 Crick labsSergi Garcia-ManyesFull details New approaches for improving outcomes in breast cancer in Europe Authors (9) Angelo Di Leo Giuseppe Curigliano Véronique Diéras Luca Malorni Christos SotiriouCharles Swanton Alastair Thompson Andrew Tutt Martine Piccart Breast Published 31 March 2015 Crick labsCharles SwantonFull details STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles Authors (16) Jalila Alshekaili Rochna Chand Cindy Eunhee Lee Susan Corley Kristy Kwong Ilenia Papa[...] Gulbu Uzel Chris C GoodnowCarola Vinuesa Stuart G Tangye Matthew C Cook Scientific Reports Published 23 February 2018 Crick labsCarola VinuesaFull details Factor inhibiting HIF can catalyse two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins Authors (16) Thomas M Leissing Adam P Hardy Hokfung Chan Yihua Wang Anthony Tumber Rasheduzzaman Chowdhury[...] Roman Fischer Benedikt M KesslerPeter Ratcliffe Xin Lu Christopher J Schofield Journal of Biological Chemistry Published 1 June 2022 Crick labsPeter RatcliffeFull details Report on computational assessment of tumor infiltrating lymphocytes from the International Immuno-Oncology Biomarker Working Group Authors (69) M Amgad ES Stovgaard E Balslev J Thagaard W Chen S Dudgeon[...] U Kurkure M Barnes R Salgado LAD Cooper International Immuno-Oncology Biomarker Working Group npj Breast Cancer Published 12 May 2020 Crick labsCharles SwantonFull details Development of a fluorogenic ADAMTS-7 substrate Authors (11) Salvatore Santamaria Frederic Buemi Elisa Nuti Doretta Cuffaro Elena De Vita Tiziano Tuccinardi Armando Rossello Steven HowellShahid MehmoodBram Snijders Rens de Groot Journal of Enzyme Inhibition and Medicinal Chemistry Published 30 September 2021 Crick labs/ facilitiesProteomicsFull details A temporal window for signal activation dictates the dimensions of a nodal signaling domain Authors (6) Antonius L van Boxtel John E Chesebro Claire HeliotMarie-Christine RamelRichard StoneCaroline Hill Developmental Cell Published 26 October 2015 Crick labs/ facilitiesCaroline HillExperimental HistopathologyLight MicroscopyBioinformatics and BiostatisticsAdvanced SequencingFull details Tumor evolution as a therapeutic target Authors (3) Nabil Amirouchene-AngelozziCharles Swanton Alberto Bardelli Cancer Discovery Published 20 July 2017 Crick labsCharles SwantonFull details Inhibition of LRRK2 kinase activity stimulates macroautophagy Authors (10) Claudia Manzoni Adamantios Mamais Sybille Dihanich Rosella Abeti Marc PM Soutar Helene Plun-Favreau Paola GiuntiSharon Tooze Rina Bandopadhyay Patrick A Lewis Biochimica et Biophysica Acta Published 1 December 2013 Crick labsSharon ToozeFull details TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation Authors (3)Daniel Miller Bernhard SchmiererCaroline Hill Journal of Cell Science Published 15 July 2019 Crick labs/ facilitiesCaroline HillCell ServicesFull details Pagination First page First Previous page Previous … Page 36 Page 37 Page 38 Page 39 Current page 40 Page 41 Page 42 Page 43 Page 44 … Next page Next Last page Last
Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding Authors (3) Amy EM Beedle Steven LynhamSergi Garcia-Manyes Nature Communications Published 22 August 2016 Crick labsSergi Garcia-ManyesFull details
New approaches for improving outcomes in breast cancer in Europe Authors (9) Angelo Di Leo Giuseppe Curigliano Véronique Diéras Luca Malorni Christos SotiriouCharles Swanton Alastair Thompson Andrew Tutt Martine Piccart Breast Published 31 March 2015 Crick labsCharles SwantonFull details
STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles Authors (16) Jalila Alshekaili Rochna Chand Cindy Eunhee Lee Susan Corley Kristy Kwong Ilenia Papa[...] Gulbu Uzel Chris C GoodnowCarola Vinuesa Stuart G Tangye Matthew C Cook Scientific Reports Published 23 February 2018 Crick labsCarola VinuesaFull details
Factor inhibiting HIF can catalyse two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins Authors (16) Thomas M Leissing Adam P Hardy Hokfung Chan Yihua Wang Anthony Tumber Rasheduzzaman Chowdhury[...] Roman Fischer Benedikt M KesslerPeter Ratcliffe Xin Lu Christopher J Schofield Journal of Biological Chemistry Published 1 June 2022 Crick labsPeter RatcliffeFull details
Report on computational assessment of tumor infiltrating lymphocytes from the International Immuno-Oncology Biomarker Working Group Authors (69) M Amgad ES Stovgaard E Balslev J Thagaard W Chen S Dudgeon[...] U Kurkure M Barnes R Salgado LAD Cooper International Immuno-Oncology Biomarker Working Group npj Breast Cancer Published 12 May 2020 Crick labsCharles SwantonFull details
Development of a fluorogenic ADAMTS-7 substrate Authors (11) Salvatore Santamaria Frederic Buemi Elisa Nuti Doretta Cuffaro Elena De Vita Tiziano Tuccinardi Armando Rossello Steven HowellShahid MehmoodBram Snijders Rens de Groot Journal of Enzyme Inhibition and Medicinal Chemistry Published 30 September 2021 Crick labs/ facilitiesProteomicsFull details
A temporal window for signal activation dictates the dimensions of a nodal signaling domain Authors (6) Antonius L van Boxtel John E Chesebro Claire HeliotMarie-Christine RamelRichard StoneCaroline Hill Developmental Cell Published 26 October 2015 Crick labs/ facilitiesCaroline HillExperimental HistopathologyLight MicroscopyBioinformatics and BiostatisticsAdvanced SequencingFull details
Tumor evolution as a therapeutic target Authors (3) Nabil Amirouchene-AngelozziCharles Swanton Alberto Bardelli Cancer Discovery Published 20 July 2017 Crick labsCharles SwantonFull details
Inhibition of LRRK2 kinase activity stimulates macroautophagy Authors (10) Claudia Manzoni Adamantios Mamais Sybille Dihanich Rosella Abeti Marc PM Soutar Helene Plun-Favreau Paola GiuntiSharon Tooze Rina Bandopadhyay Patrick A Lewis Biochimica et Biophysica Acta Published 1 December 2013 Crick labsSharon ToozeFull details
TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation Authors (3)Daniel Miller Bernhard SchmiererCaroline Hill Journal of Cell Science Published 15 July 2019 Crick labs/ facilitiesCaroline HillCell ServicesFull details