Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Search Results Fulltext search 896 Results Found Neurodegeneration cell per cell Authors (5) Sriram Balusu Roman Praschberger Elsa LauwersBart De Strooper Patrik Verstreken Neuron Published 15 March 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details Mutant exon1 Huntingtin aggregation is regulated by T3 phosphorylation-induced structural changes and crosstalk between T3 phosphorylation and acetylation at K6 Authors (12) A Chiki SM DeGuire FS Ruggeri D Sanfelice A Ansaloni Z-M Wang[...] R Burai S Vieweg A Pastore G Dietler HA Lashuel Angewandte Chemie International Edition Published 1 May 2017Full details Mitochondrial permeability transition: A molecular lesion with multiple drug targets Authors (4) Thomas Briston David L Selwood Gyorgy Szabadkai Michael R Duchen Trends in Pharmacological Sciences Published 1 January 2019Full details Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis Authors (10) John S O'Neill Nathaniel P Hoyle J Brian Robertson Rachel S Edgar Andrew D Beale Sew Y Peak-Chew Jason Day Ana SH Costa Christian Frezza Helen C Causton Nature Communications Published 17 September 2020Full details Mechanism of β-actin mRNA recognition by ZBP1 Authors (8)Giuseppe Nicastro Adela M Candel Michael UhlAlain Oregioni David Hollingworth Rolf Backofen Stephen R Martin Andres Ramos Cell Reports Published 31 January 2017 Crick labs/ facilitiesIan TaylorMRC Biomedical NMR CentreStructural BiologyMRC Biomedical NMR CentreProteomicsFull details Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis Authors (17) Adeline Rosu Najla El Hachem Francesca RapinoKevin Rouault-Pierre Joseph Jorssen Joan Somja[...]Dominique Bonnet Alain Chariot Pierre Close Fabrice Bureau Christophe J Desmet Journal of Experimental Medicine Published 1 March 2021 Crick labsDominique BonnetFull details Human CD34+ hematopoietic stem cell hierarchy: how far are we with its delineation at the most primitive level? Authors (2)Fernando Dos Anjos AfonsoDominique Bonnet Blood Published 10 August 2023 Crick labsDominique BonnetFull details 3ʹ UTR length and messenger ribonucleoprotein composition determine endocleavage efficiencies at termination codons Authors (5) Volker Boehm Nejc Haberman Franziska OttensJernej Ule Niels H Gehring Cell Reports Published 23 October 2014 Crick labsJernej UleFull details CLIPing the brain: studies of protein-RNA interactions important for neurodegenerative disorders Authors (3) Miha ModicJernej Ule Christopher R Sibley Molecular and Cellular Neurosciences Published 1 September 2013 Crick labsJernej UleFull details Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop Authors (44) Glyn Stacey Peter Andrews Curtis Asante Ivana Barbaric Jaqueline Barry Louise Bisset[...] Marc Turner Ludovic Vallier Loriana Vitillo Andrew Webster David Williams Regenerative Medicine Published 29 November 2018 Crick labs/ facilitiesHuman Embryonic Stem CellFull details Pagination First page First Previous page Previous … Page 37 Page 38 Page 39 Page 40 Current page 41 Page 42 Page 43 Page 44 Page 45 … Next page Next Last page Last
Neurodegeneration cell per cell Authors (5) Sriram Balusu Roman Praschberger Elsa LauwersBart De Strooper Patrik Verstreken Neuron Published 15 March 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
Mutant exon1 Huntingtin aggregation is regulated by T3 phosphorylation-induced structural changes and crosstalk between T3 phosphorylation and acetylation at K6 Authors (12) A Chiki SM DeGuire FS Ruggeri D Sanfelice A Ansaloni Z-M Wang[...] R Burai S Vieweg A Pastore G Dietler HA Lashuel Angewandte Chemie International Edition Published 1 May 2017Full details
Mitochondrial permeability transition: A molecular lesion with multiple drug targets Authors (4) Thomas Briston David L Selwood Gyorgy Szabadkai Michael R Duchen Trends in Pharmacological Sciences Published 1 January 2019Full details
Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis Authors (10) John S O'Neill Nathaniel P Hoyle J Brian Robertson Rachel S Edgar Andrew D Beale Sew Y Peak-Chew Jason Day Ana SH Costa Christian Frezza Helen C Causton Nature Communications Published 17 September 2020Full details
Mechanism of β-actin mRNA recognition by ZBP1 Authors (8)Giuseppe Nicastro Adela M Candel Michael UhlAlain Oregioni David Hollingworth Rolf Backofen Stephen R Martin Andres Ramos Cell Reports Published 31 January 2017 Crick labs/ facilitiesIan TaylorMRC Biomedical NMR CentreStructural BiologyMRC Biomedical NMR CentreProteomicsFull details
Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis Authors (17) Adeline Rosu Najla El Hachem Francesca RapinoKevin Rouault-Pierre Joseph Jorssen Joan Somja[...]Dominique Bonnet Alain Chariot Pierre Close Fabrice Bureau Christophe J Desmet Journal of Experimental Medicine Published 1 March 2021 Crick labsDominique BonnetFull details
Human CD34+ hematopoietic stem cell hierarchy: how far are we with its delineation at the most primitive level? Authors (2)Fernando Dos Anjos AfonsoDominique Bonnet Blood Published 10 August 2023 Crick labsDominique BonnetFull details
3ʹ UTR length and messenger ribonucleoprotein composition determine endocleavage efficiencies at termination codons Authors (5) Volker Boehm Nejc Haberman Franziska OttensJernej Ule Niels H Gehring Cell Reports Published 23 October 2014 Crick labsJernej UleFull details
CLIPing the brain: studies of protein-RNA interactions important for neurodegenerative disorders Authors (3) Miha ModicJernej Ule Christopher R Sibley Molecular and Cellular Neurosciences Published 1 September 2013 Crick labsJernej UleFull details
Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop Authors (44) Glyn Stacey Peter Andrews Curtis Asante Ivana Barbaric Jaqueline Barry Louise Bisset[...] Marc Turner Ludovic Vallier Loriana Vitillo Andrew Webster David Williams Regenerative Medicine Published 29 November 2018 Crick labs/ facilitiesHuman Embryonic Stem CellFull details