Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Search Results Fulltext search 895 Results Found Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology Authors (17) Renzo Mancuso Nicola Fattorelli Anna Martinez-MurianaEmma Davis Leen Wolfs Johanna Van Den Daele[...] Suresh Poovathingal Sriram Balusu Catherine Verfaillie Mark FiersBart De Strooper Nature Neuroscience Published 27 March 2024 Crick labsBart de Strooper | Lorena ArancibiaFull details Mechanisms of hypoxia signalling: new implications for nephrology Authors (2) Johannes SchödelPeter Ratcliffe Nature Reviews Nephrology Published 1 October 2019 Crick labsPeter RatcliffeFull details Mechanism of oxidative stress in neurodegeneration Authors (2)Sonia Gandhi Andrey Y Abramov Oxidative Medicine and Cellular Longevity Published 1 January 2012 Crick labsSonia GandhiFull details Human stem cell-derived astrocytes: Specification and relevance for neurological disorders Authors (3)Giulia Tyzack Andras LakatosRickie Patani Current Stem Cell Reports Published 1 January 2016 Crick labsRickie PataniFull details mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis Authors (16) Brintha Selvarajah Ilan Azuelos Manuela Platé Delphine Guillotin Ellen J Forty Greg Contento[...] Riccardo Ronzoni Andy D Blanchard Paul F MercerDimitrios Anastasiou Rachel C Chambers Science Signaling Published 21 May 2019 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsFull details Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes Authors (8) Gerd Specht Hanna P Roetschke Artem Mansurkhodzhaev Petra Henklein Kathrin Textoris-Taube Henning UrlaubMichele Mishto Juliane Liepe Scientific Data Published 15 May 2020 Crick labsMichele MishtoFull details TDP-43 regulates its mRNA levels through a negative feedback loop Authors (11) Youhna M Ayala Laura De Conti S Eréndira Avendaño-Vázquez Ashish Dhir Maurizio Romano Andrea D'Ambrogio James TollerveyJernej Ule Marco Baralle Emanuele Buratti Francisco E Baralle EMBO Journal Published 19 January 2011 Crick labsJernej UleFull details Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders Authors (25) Sandra Blanco Sabine Dietmann Joana V Flores Shobbir Hussain Claudia Kutter Peter Humphreys[...] Mark HelmJernej Ule Joseph G Gleeson Duncan T Odom Michaela Frye EMBO Journal Published 17 September 2014 Crick labsJernej UleFull details Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2 Authors (6) Matthew A Child Philippa K Harris Christine R CollinsChrislaine Withers-Martinez Sharon YeohMichael Blackman Traffic Published 1 January 2013 Crick labsMike BlackmanFull details Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities Authors (17) Arttu Jolma Teemu Kivioja Jarkko Toivonen Lu Cheng Gonghong Wei Martin Enge[...] Shaheynoor Talukder Timothy R HughesNicholas Luscombe Esko Ukkonen Jussi Taipale Genome Research Published 1 June 2010 Crick labsNicholas LuscombeFull details Pagination First page First Previous page Previous … Page 58 Page 59 Page 60 Page 61 Current page 62 Page 63 Page 64 Page 65 Page 66 … Next page Next Last page Last
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology Authors (17) Renzo Mancuso Nicola Fattorelli Anna Martinez-MurianaEmma Davis Leen Wolfs Johanna Van Den Daele[...] Suresh Poovathingal Sriram Balusu Catherine Verfaillie Mark FiersBart De Strooper Nature Neuroscience Published 27 March 2024 Crick labsBart de Strooper | Lorena ArancibiaFull details
Mechanisms of hypoxia signalling: new implications for nephrology Authors (2) Johannes SchödelPeter Ratcliffe Nature Reviews Nephrology Published 1 October 2019 Crick labsPeter RatcliffeFull details
Mechanism of oxidative stress in neurodegeneration Authors (2)Sonia Gandhi Andrey Y Abramov Oxidative Medicine and Cellular Longevity Published 1 January 2012 Crick labsSonia GandhiFull details
Human stem cell-derived astrocytes: Specification and relevance for neurological disorders Authors (3)Giulia Tyzack Andras LakatosRickie Patani Current Stem Cell Reports Published 1 January 2016 Crick labsRickie PataniFull details
mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis Authors (16) Brintha Selvarajah Ilan Azuelos Manuela Platé Delphine Guillotin Ellen J Forty Greg Contento[...] Riccardo Ronzoni Andy D Blanchard Paul F MercerDimitrios Anastasiou Rachel C Chambers Science Signaling Published 21 May 2019 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsFull details
Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes Authors (8) Gerd Specht Hanna P Roetschke Artem Mansurkhodzhaev Petra Henklein Kathrin Textoris-Taube Henning UrlaubMichele Mishto Juliane Liepe Scientific Data Published 15 May 2020 Crick labsMichele MishtoFull details
TDP-43 regulates its mRNA levels through a negative feedback loop Authors (11) Youhna M Ayala Laura De Conti S Eréndira Avendaño-Vázquez Ashish Dhir Maurizio Romano Andrea D'Ambrogio James TollerveyJernej Ule Marco Baralle Emanuele Buratti Francisco E Baralle EMBO Journal Published 19 January 2011 Crick labsJernej UleFull details
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders Authors (25) Sandra Blanco Sabine Dietmann Joana V Flores Shobbir Hussain Claudia Kutter Peter Humphreys[...] Mark HelmJernej Ule Joseph G Gleeson Duncan T Odom Michaela Frye EMBO Journal Published 17 September 2014 Crick labsJernej UleFull details
Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2 Authors (6) Matthew A Child Philippa K Harris Christine R CollinsChrislaine Withers-Martinez Sharon YeohMichael Blackman Traffic Published 1 January 2013 Crick labsMike BlackmanFull details
Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities Authors (17) Arttu Jolma Teemu Kivioja Jarkko Toivonen Lu Cheng Gonghong Wei Martin Enge[...] Shaheynoor Talukder Timothy R HughesNicholas Luscombe Esko Ukkonen Jussi Taipale Genome Research Published 1 June 2010 Crick labsNicholas LuscombeFull details