Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Search Results Fulltext search 756 Results Found Somatic TP53 mutations are detectable in circulating tumor DNA from children with anaplastic Wilms tumors Authors (11) Taryn D Treger Tasnim Chagtai Robert Butcher George D Cresswell Reem Al-Saadi Jesper Brok Richard D Williams Chrissy RobertsNicholas Luscombe Kathy Pritchard Jones William Mifsud Translational Oncology Published 1 December 2018 Crick labsNicholas LuscombeFull details Quantitative neurobiological evidence for accelerated brain aging in alcohol dependence Authors (11) Matthias GuggenmosKatharina Schmack Maria Sekutowicz Maria Garbusow Miriam Sebold Christian Sommer Michael N Smolka Hans-Ulrich Wittchen Ulrich S Zimmermann Andreas Heinz Philipp Sterzer Translational Psychiatry Published 11 December 2017 Crick labsKatharina SchmackFull details Promoting scientific entrepreneurship Our scientists care about the impact of their work - the Crick has a unique culture of translation where innovation and entrepreneurship is encouraged and celebrated. Breadcrumb Research Applying our research The Francis Crick Institute: scientific discovery open to translation Authors (1) David Roblin Pharmaceutical Medicine Published 1 January 2016Full details Optimal translational termination requires C4 lysyl hydroxylation of eRF1 Authors (22) Tianshu Feng Atsushi Yamamoto Sarah E Wilkins Elizaveta Sokolova Luke A Yates Martin Münzel[...] Ludmila Y Frolova Elena AlkalaevaPeter Ratcliffe Christopher J Schofield Mathew L Coleman Molecular Cell Published 20 February 2014 Crick labsPeter RatcliffeFull details MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration Authors (34) Roberto Simone Faiza Javad Warren EmmettOscar Wilkins Filipa Lourenço Almeida Natalia Barahona-Torres[...] Per Svenningsson Thomas T Warner Vincent PlagnolJernej Ule Rohan de Silva Nature Published 3 June 2021 Crick labsJernej UleRickie PataniFull details Stops making sense: translational trade-offs and stop codon reassignment Authors (7) LJ Johnson JA Cotton CP Lichtenstein GS Elgar RA Nichols PD Polly SC Le Comber BMC Evolutionary Biology Published 29 July 2011Full details Translation stress and collided ribosomes are co-activators of cGAS Authors (11)Li Wan Szymon Juszkiewicz Daniel Blears Prashanth Kumar Bajpe Zhong HanPeter Faull Richard MitterAengus StewartBram Snijders Ramanujan S HegdeJesper Svejstrup Molecular Cell Published 1 July 2021 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryCell ServicesAdvanced SequencingFull details Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy Authors (12) Christoph Loenarz Rok Sekirnik Armin Thalhammer Wei Ge Ekaterina Spivakovsky Mukram M Mackeen[...]Matthew Cockman Benedikt M KesslerPeter Ratcliffe Alexander Wolf Christopher J Schofield Proceedings of the National Academy of Sciences of the United States of America Published 18 March 2014 Crick labsPeter RatcliffeFull details Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications Authors (9) Kuo-Feng Hsu Sarah E Wilkins Richard J Hopkinson Rok Sekirnik Emily Flashman Akane Kawamura James SO McCullaghLouise Walport Christopher J Schofield Epigenetics Published 1 January 2021 Crick labsLouise WalportFull details Pagination First page First Previous page Previous … Page 4 Page 5 Page 6 Page 7 Current page 8 Page 9 Page 10 Page 11 Page 12 … Next page Next Last page Last
Somatic TP53 mutations are detectable in circulating tumor DNA from children with anaplastic Wilms tumors Authors (11) Taryn D Treger Tasnim Chagtai Robert Butcher George D Cresswell Reem Al-Saadi Jesper Brok Richard D Williams Chrissy RobertsNicholas Luscombe Kathy Pritchard Jones William Mifsud Translational Oncology Published 1 December 2018 Crick labsNicholas LuscombeFull details
Quantitative neurobiological evidence for accelerated brain aging in alcohol dependence Authors (11) Matthias GuggenmosKatharina Schmack Maria Sekutowicz Maria Garbusow Miriam Sebold Christian Sommer Michael N Smolka Hans-Ulrich Wittchen Ulrich S Zimmermann Andreas Heinz Philipp Sterzer Translational Psychiatry Published 11 December 2017 Crick labsKatharina SchmackFull details
Promoting scientific entrepreneurship Our scientists care about the impact of their work - the Crick has a unique culture of translation where innovation and entrepreneurship is encouraged and celebrated. Breadcrumb Research Applying our research
The Francis Crick Institute: scientific discovery open to translation Authors (1) David Roblin Pharmaceutical Medicine Published 1 January 2016Full details
Optimal translational termination requires C4 lysyl hydroxylation of eRF1 Authors (22) Tianshu Feng Atsushi Yamamoto Sarah E Wilkins Elizaveta Sokolova Luke A Yates Martin Münzel[...] Ludmila Y Frolova Elena AlkalaevaPeter Ratcliffe Christopher J Schofield Mathew L Coleman Molecular Cell Published 20 February 2014 Crick labsPeter RatcliffeFull details
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration Authors (34) Roberto Simone Faiza Javad Warren EmmettOscar Wilkins Filipa Lourenço Almeida Natalia Barahona-Torres[...] Per Svenningsson Thomas T Warner Vincent PlagnolJernej Ule Rohan de Silva Nature Published 3 June 2021 Crick labsJernej UleRickie PataniFull details
Stops making sense: translational trade-offs and stop codon reassignment Authors (7) LJ Johnson JA Cotton CP Lichtenstein GS Elgar RA Nichols PD Polly SC Le Comber BMC Evolutionary Biology Published 29 July 2011Full details
Translation stress and collided ribosomes are co-activators of cGAS Authors (11)Li Wan Szymon Juszkiewicz Daniel Blears Prashanth Kumar Bajpe Zhong HanPeter Faull Richard MitterAengus StewartBram Snijders Ramanujan S HegdeJesper Svejstrup Molecular Cell Published 1 July 2021 Crick labs/ facilitiesJesper SvejstrupProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryCell ServicesAdvanced SequencingFull details
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy Authors (12) Christoph Loenarz Rok Sekirnik Armin Thalhammer Wei Ge Ekaterina Spivakovsky Mukram M Mackeen[...]Matthew Cockman Benedikt M KesslerPeter Ratcliffe Alexander Wolf Christopher J Schofield Proceedings of the National Academy of Sciences of the United States of America Published 18 March 2014 Crick labsPeter RatcliffeFull details
Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications Authors (9) Kuo-Feng Hsu Sarah E Wilkins Richard J Hopkinson Rok Sekirnik Emily Flashman Akane Kawamura James SO McCullaghLouise Walport Christopher J Schofield Epigenetics Published 1 January 2021 Crick labsLouise WalportFull details
