Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Search Results Fulltext search 758 Results Found Genome-wide association studies in Crohn's disease: Past, present and future Authors (3) Bram Verstockt Kenneth GC SmithJames Lee Clinical and Translational Immunology Published 1 January 2018 Crick labsJames LeeFull details Intratumor heterogeneity: seeing the wood for the trees Authors (5) Timothy A Yap Marco Gerlinger P Andrew Futreal Lajos PusztaiCharles Swanton Science Translational Medicine Published 28 March 2012 Crick labsCharles SwantonFull details Neoantigen quality, not quantity Authors (2) Nicholas McGranahanCharles Swanton Science Translational Medicine Published 21 August 2019 Crick labsCharles SwantonFull details Neurodegeneration: From cellular concepts to clinical applications Authors (3) Alla KatsnelsonBart De Strooper Huda Y Zoghbi Science Translational Medicine Published 9 November 2016 Crick labsBart de Strooper | Lorena ArancibiaFull details Hydrogel viscoelasticity modulates migration and fusion of mesenchymal stem cell spheroids Authors (6) David T Wu Mani Diba Stephanie Yang Benjamin R FreedmanAlberto Elosegui Artola David J Mooney Bioengineering and Translational Medicine Published 27 December 2022 Crick labsAlberto Elosegui ArtolaFull details S95021, a novel selective and pan-neutralizing anti interferon alpha (IFN-α) monoclonal antibody as a candidate treatment for selected autoimmune rheumatic diseases Authors (14) Fanny Duguet Céline Ortega-Ferreira Benjamin Fould Hélène Darville Sylvie Berger Agnès Chomel[...]Adrian Hayday Emiko Desvaux Emmanuel Nony Philippe Moingeon Frédéric De Ceuninck Journal of Translational Autoimmunity Published 1 March 2021 Crick labsAdrian HaydayFull details Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition Authors (13) Roger A Habets Charles E de Bock Lutgarde Serneels Inge Lodewijckx Delphine Verbeke David Nittner[...] James Dooley Adrian Liston Tom Taghon Jan CoolsBart De Strooper Science Translational Medicine Published 29 May 2019 Crick labsBart de Strooper | Lorena ArancibiaFull details Disease extent and anti-tubercular treatment response correlates with Mycobacterium tuberculosis-specific CD4 T-cell phenotype regardless of HIV-1 status Authors (9) Catherine Riou Elsa Du Bruyn Sheena Ruzive Rene T Goliath Cecilia S Lindestam Arlehamn Alessandro Sette Alan Sher Daniel L BarberRobert Wilkinson Clinical and Translational Immunology Published 28 September 2020 Crick labsRobert J WilkinsonFull details Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors Authors (35) Dennis Plenker Maximilian Riedel Johannes Brägelmann Marcel A DammertRakhee Chauhan Phillip P Knowles[...]Neil McDonald Stefan M Kast Oliver Gautschi Roman K Thomas Martin L Sos Science Translational Medicine Published 14 June 2017 Crick labsNeil McDonaldFull details Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis Authors (52) Claire Vennin Venessa T Chin Sean C Warren Morghan C Lucas David Herrmann Astrid Magenau[...] Andrew Burgess Thomas R Cox Jennifer P Morton Marina Pajic Paul Timpson Science Translational Medicine Published 5 April 2017 Crick labs/ facilitiesLight MicroscopyFull details Pagination First page First Previous page Previous … Page 5 Page 6 Page 7 Page 8 Current page 9 Page 10 Page 11 Page 12 Page 13 … Next page Next Last page Last
Genome-wide association studies in Crohn's disease: Past, present and future Authors (3) Bram Verstockt Kenneth GC SmithJames Lee Clinical and Translational Immunology Published 1 January 2018 Crick labsJames LeeFull details
Intratumor heterogeneity: seeing the wood for the trees Authors (5) Timothy A Yap Marco Gerlinger P Andrew Futreal Lajos PusztaiCharles Swanton Science Translational Medicine Published 28 March 2012 Crick labsCharles SwantonFull details
Neoantigen quality, not quantity Authors (2) Nicholas McGranahanCharles Swanton Science Translational Medicine Published 21 August 2019 Crick labsCharles SwantonFull details
Neurodegeneration: From cellular concepts to clinical applications Authors (3) Alla KatsnelsonBart De Strooper Huda Y Zoghbi Science Translational Medicine Published 9 November 2016 Crick labsBart de Strooper | Lorena ArancibiaFull details
Hydrogel viscoelasticity modulates migration and fusion of mesenchymal stem cell spheroids Authors (6) David T Wu Mani Diba Stephanie Yang Benjamin R FreedmanAlberto Elosegui Artola David J Mooney Bioengineering and Translational Medicine Published 27 December 2022 Crick labsAlberto Elosegui ArtolaFull details
S95021, a novel selective and pan-neutralizing anti interferon alpha (IFN-α) monoclonal antibody as a candidate treatment for selected autoimmune rheumatic diseases Authors (14) Fanny Duguet Céline Ortega-Ferreira Benjamin Fould Hélène Darville Sylvie Berger Agnès Chomel[...]Adrian Hayday Emiko Desvaux Emmanuel Nony Philippe Moingeon Frédéric De Ceuninck Journal of Translational Autoimmunity Published 1 March 2021 Crick labsAdrian HaydayFull details
Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition Authors (13) Roger A Habets Charles E de Bock Lutgarde Serneels Inge Lodewijckx Delphine Verbeke David Nittner[...] James Dooley Adrian Liston Tom Taghon Jan CoolsBart De Strooper Science Translational Medicine Published 29 May 2019 Crick labsBart de Strooper | Lorena ArancibiaFull details
Disease extent and anti-tubercular treatment response correlates with Mycobacterium tuberculosis-specific CD4 T-cell phenotype regardless of HIV-1 status Authors (9) Catherine Riou Elsa Du Bruyn Sheena Ruzive Rene T Goliath Cecilia S Lindestam Arlehamn Alessandro Sette Alan Sher Daniel L BarberRobert Wilkinson Clinical and Translational Immunology Published 28 September 2020 Crick labsRobert J WilkinsonFull details
Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors Authors (35) Dennis Plenker Maximilian Riedel Johannes Brägelmann Marcel A DammertRakhee Chauhan Phillip P Knowles[...]Neil McDonald Stefan M Kast Oliver Gautschi Roman K Thomas Martin L Sos Science Translational Medicine Published 14 June 2017 Crick labsNeil McDonaldFull details
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis Authors (52) Claire Vennin Venessa T Chin Sean C Warren Morghan C Lucas David Herrmann Astrid Magenau[...] Andrew Burgess Thomas R Cox Jennifer P Morton Marina Pajic Paul Timpson Science Translational Medicine Published 5 April 2017 Crick labs/ facilitiesLight MicroscopyFull details
