Crick Cancer Research Symposium

• 10:00 - Registration with tea and coffee
• 11:00 - Peter Friedl (The University of Texas MD Anderson Cancer Center) - 'Mechanochemical plasticity of cancer invasion in vivo'
• 11:30 - Marco Montagner (Francis Crick Institute) - short talk: 'Epithelial cell cross-talk regulates sFRP2 expression enabling breast cancer latency'
• 11:45 - Victoria Sanz-Moreno (King's College London) - 'The role of actomyosin contractility in cancer invasion and the microenvironment'
• 12:15 - Paul Grevitt (Barts Cancer Institute) - short talk: 'The role of CoAsy as a negative regulator of Hypoxia Inducible Factors in cancer'
• 12:30 - Lunch & careers workshop (optional)
• 14:00 - Sophie Acton (University College London) - ‘Lessons from lymph nodes – leukocyte/stromal cell cross talk in tumour microenvironments’
• 14:30 - Louise Johnson (University of Oxford) - short talk: 'Regulation of leukocyte and tumour cell trafficking in lymphatics by the hyaluronan receptor LYVE-1'
• 14:45 - Paul Kennedy (Barts Cancer Institute) - short talk: 'Loss of the tumour suppressor LIMD1 alters PD-L1 regulation in cancer'
• 15:00 - Christian Ottensmeier (University of Southampton) - 'Predicting responses from immunotherapy using molecular tools'
• 15:30 - Refreshment break
• 16:00 - Yinyin Yuan (Institute of Cancer Research) 'Deciphering the tumour ecosystem with spatial histology'
• 16:30 - Flash talks: Stelios Chrysostomou (Imperial College London); Lisa Del Bel Belluz (Imperial College London); Geoffrey Maher (University of Oxford); Xueying Mao (Barts Cancer Institute); Miriam Molina (Francis Crick Institute); Dimitra Repana (Francis Crick Institute)
• 17:00 - Keynote - Rene Bernards (Netherlands Cancer Institute) - 'A one-two punch model for cancer therapy'
• 17:45-20:00 -  Poster session with finger food and drinks reception

• 09:00 - Kairbaan Hodivala-Dilke (Barts Cancer Institute) - 'The tumour stroma – New ways for old roads'
• 09:30 - Oliver Cast (University of Cambridge) - short talk: 'Comprehensive Benchmarking and Integration of Bioinformatic Approaches to Tumour Microenvironment Cell Estimation Using Bulk Tumour RNA Data'
• 09:45 - Louise Fets (Francis Crick Institute) - short talk: 'MCT2-mediated MOG transport dictates intracellular target engagement to drive toxicity in cancer cells'
• 10:00 - Refreshment break
• 10:30 - Martin Pule (University College London) - 'T-cell engineering for cancer applications'
• 11:00 - Walid Khaled (University of Cambridge) - short talk: 'The study of mammary epithelial cell differentiation dynamics and breast cancer development by single cell RNA sequencing'
• 11:15 - Sara Waise (University of Southampton) - short talk: 'Characterising heterogeneity in the cancer-associated fibroblast population in non-small cell lung cancer: relating phenotype to function'
• 11:30 - Binzhi Qian (University of Edinburgh) - 'Macrophage heterogeneity in breast cancer metastasis'
• 12:00 - Lunch & poster session
• 13:30 - Inigo Martincorena (Wellcome Sanger Institute) - 'Somatic evolution in cancer and normal tissues'
• 14:00 - Greti Espona-Fiedler (Queen's University Belfast) - short talk: 'On-target and MoA studies of first-in-class FLIP inhibitors in lung and colorectal cancer cell models'
• 14:15 - Paola Scaffidi (Francis Crick Institute) - 'Epigenetic mechanisms of cancer cell self-renewal'
• 14:45 - Refreshment break
• 15:15 - Sakari Vanharanta (University of Cambridge) - short talk: 'Cross-lineage enhancer co-option as a source of metastatic traits'
• 15:30 - Laura Novellasedemunt (Francis Crick Institute) - short talk: 'USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating b-Catenin Deubiquitination'
• 15:45 - Gerard Evan (University of Cambridge) 'Where cancer phenotypes come from and how to make them go away'
• 16:15 - Concluding remarks

The full symposium booklet is available to download.

Crick Cancer Research Symposium booklet (pdf)

The poster abstracts for the conference are available to download.

Poster abstracts (pdf)