Crick Lecture | Ivan Đikić

Crick Lectures

Crick Lectures are delivered by leading internationally-renowned scientists from the Francis Crick Institute and elsewhere and cover the full spectrum of biomedical research. They aim to be relatively accessible to scientists in all biomedical disciplines, whilst also offering something for the specialist.

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The Dikic Molecular Signaling laboratory focuses on studying molecular mechanisms of the two major degradation pathways – the ubiquitin-proteasome system (UPS) and autophagy. Degradation of cellular components, either through the UPS or the lysosome (autophagy), is essential for maintaining cellular homeostasis. Disruption to either of the processes can lead to neurodegenerative diseases, cancer and other pathologies. It is critical to understand the structure and function of individual components within each of these pathways.