Mark Ellisman is a professor of neurosciences and bioengineering and director of the Centre for Research in Biological Systems at the University of California, San Diego (UCSD). He received his PhD in molecular, cellular and developmental biology at the University of Colorado in 1976, and has been a professor at UCSD since 1977.
Ellisman directs the National Centre for Microscopy and Imaging Research (NCMIR), an internationally acclaimed technology development centre and research resource established by the National Institutes for Health (NIH) in the USA.
He is a pioneer in the development of 3D light and electron microscopy and emphasizes application of these imaging strategies to the study of brains and the many types of cells, which form nervous systems. He collaborated with Roger Y. Tsien for nearly 30 years, developing new probe technologies for correlated light and electron microscopy. Current efforts include new probe, instrument and technique development for multiscale and multimodal imaging - all at the frontiers of microscopy, computer science and computational biology.
He and his group determined that LRRK2 binds to microtubules and decorates them in an organized manner. His lab works on alpha-synuclein and LRRK2 as well as other aspects of Parkinson’s and neurodegenerative diseases.