A lecture taking place at the Crick.

: Mechanistic Enzymology and Bacterial Drug Resistance

John S Blanchard

Professor | Dan Danciger Professor of Biochemistry, Albert Einstein College of Medicine, New York, USA

For forty years, my laboratory has been interested in the mechanisms by which enzymes catalyze their reactions and the tremendous rate accelerations achieved. To date, we have studied over 75 individual enzyme reactions of all different types. In the last twenty-five years, we have focused our attention on enzymes from bacterial pathogens, specifically Mycobacterium tuberculosis. A subset of these enzymes is responsible for resistance to antibacterial compounds including aminoglycosides, fluoroquinolones and beta-lactams. Several examples of our combined structure-function-mechanistic studies will be presented.

Host: Luiz Pedro Carvalho

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