Autophagy and Medicine: Maintaining Health and Preventing Disease
Our seventh Medicine at the Crick event will be hosted by Dr Rupert Beale and includes a keynote talk from Dr Herbert (Skip) Virgin of Vir Biotechnology Inc.
Autophagy is a process by which cells engulf their own contents and digest them – literally self-eating. It plays multiple roles in maintaining homeostasis by for example generating nutrients, removing damaged cellular structures and targeting pathogens. Components of the autophagy machinery can be co-opted for other functions, including by pathogens.
Despite its role in many pathophysiological processes, we are only just beginning to understand how it can be manipulated to enhance health and prevent disease. The 7th event in our series presents an overview of autophagy and its functions, and a state of the art review of the roles of autophagy in neurodegeneration, infection and immunity.