Hosted by Alex Gould, this 12th edition of Medicine at the Crick will focus on recent advances in our understanding of how embryonic development influences adult disease.
The early-life environment is well established to impact upon infant health and disease. It is less widely known that it also influences the risk of adult diseases manifested many decades later. Developmentally "programmed" adult diseases are diverse and include type 2 diabetes, asthma, cardiovascular disease, neurodegenerative conditions and even some cancers. Research in this area, the developmental origins of health and disease (DOHaD), is clinically important but surprisingly still not on the radar of many developmental biologists. This Medicine at the Crick event aims to raise awareness of DOHaD research. It will highlight emerging organogenic and epigenetic links between embryonic development and adult disease. It will explore how diseases such as cancer may involve inappropriate reruns of developmental genetic programmes. Key impacts of DOHaD research on public health policy will also be discussed.
Image by Shankar Srinivas.