09.15 Registration / coffee
09.55 Opening Comments
Chair: Doug Higgs
10.00 Bertie Göttgens (University of Cambridge, UK), ‘Cell Fate Acquisition and Lineage Diversification During Early Embryonic Blood Cell Development’
10.20 Jim Hughes (Weatherall Institute of Molecular Medicine, Oxford, UK), ‘The higher order structure of gene regulatory interactions’
10.40 Kamil Kranc (University of Edinburgh, UK), ‘The role of the m6A-mediated RNA decay pathway in haematopoietic stem cell biology and leukaemic transformation’
11.00 Coffee
Chair: Tom Milne
11.30 Tim Somervaille (Cancer Research UK Manchester Institute, UK), ‘Mis-expressed transcription factors in acute leukaemia’
11.50 Christine Harrison (Northern Institute for Cancer Research, Newcastle, UK) ‘Chromosome 21: its critical role in childhood leukaemia’
12.10 Jan-Henning Klusmann (Universitätsklinikum Halle, Germany), ‘Modelling the progression of a preleukemic stage to overt leukemia in children with Down Syndrome’
12.30 Lunch
Chair: Katrin Ottersbach
14.00 Charles Durand (Sorbonne University, Paris, France), ‘The transcriptional landscape of the AGM hematopoietic microenvironment’
14.20 Joan Yuan (Lund University, Sweden), ‘Peeling back the layers of B lymphopoiesis’
14.40 Hans-Reimer Rodewald (German Cancer Research Center, Heidelberg, Germany), ‘Deconvolution of hematopoiesis by fate mapping and Polylox barcoding’
15.00 Tea
Chair: Tony Green
15.30 Nina Cabezas Wallscheid (Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany), ‘Regulation of Dormant Hematopoietic Stem Cells’
15.50 Keynote Lecture:
Gerd Blobel (University of Pennsylvania, USA), ‘Long range chromatin contacts: mechanisms and therapeutic applications’
16.50 Close and refreshments
