The Structural Biology Interest Group comprises a wide and diverse grouping of research teams that share the common goal of describing cellular function at the atomic and mechanistic level.
The biological themes under investigation reflect the wide range of research areas covered within the Crick. These include mechanisms of cellular and immune signalling, the structural biology of epigenetic regulation, DNA repair and chromosome segregation and viral assembly and infection.
To study this diverse range of systems we employ a battery of complementary biochemical, biophysical, computational and structural techniques that include, but are not limited to, X-ray crystallography, NMR spectroscopy, cryo-electron microscopy and combined spectroscopic, thermodynamic and hydrodynamic methodologies.
Our overarching goal is to understand complex biological phenomena in terms of the molecular interactions that drive and regulate them. These efforts are underpinned by a desire to open up new approaches to combat disease and many of the groups are actively involved in efforts to translate structural biology research into new medicines and treatments that will impact on global health.